Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1937822 | 0.83 | GPR119 (0.48) | GPR119CYP2C9CYP2C19 | |
| SCHEMBL903897 | 0.81 | GPR119 (0.40) | GPR119KIF11KCNH2PTGS2PTGS1 | |
| SCHEMBL903936 | 0.72 | GPR119 (0.48) | GPR119 | |
| SCHEMBL12375468 | 0.71 | GPR119 (0.48) | GPR119KCNH2CYP2C9CYP2C19 | |
| SCHEMBL1938312 | 0.70 | GPR119 (0.61) | GPR119 | |
| SCHEMBL10067568 | 0.70 | GPR119 (0.38) | GPR119KIF11 | |
| SCHEMBL1937388 | 0.70 | SLC6A9 (0.46) | GPR119KIF11KCNH2PTGS2PTGS1 | |
| SCHEMBL903924 | 0.68 | GPR119 (0.53) | GPR119 | |
| SCHEMBL10067768 | 0.68 | GPR119 (0.47) | GPR119 | |
| SCHEMBL903920 | 0.67 | GPR119 (0.50) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |