Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198514 | 0.90 | ALDH1A1 (0.51) | KDM4EAKR1C3AKR1C2SMN1; SMN2NPC1 | |
| SCHEMBL294877 | 0.89 | KDM4E (0.44) | KDM4ESMN1; SMN2NPC1ALDH1A1HSD11B1 | |
| SCHEMBL3480606 | 0.85 | LMNA (0.57) | KDM4EPOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL974920 | 0.82 | HSD11B1 (0.45) | KDM4ESMN1; SMN2ALDH1A1HSD11B1MAPT | |
| SCHEMBL13111272 | 0.82 | NPC1 (0.46) | KDM4ESMN1; SMN2NPC1ALDH1A1HSD11B1 | |
| SCHEMBL7930838 | 0.82 | ALDH1A1 (0.43) | KDM4EPOLBALDH1A1HSD11B1MEN1 | |
| SCHEMBL6551724 | 0.81 | HSD11B1 (0.46) | KDM4ENPC1HSD11B1MAPTRAB9A | |
| SCHEMBL6935409 | 0.81 | CA12 (0.55) | POLBSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6938157 | 0.81 | CA12 (0.55) | POLBSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3491420 | 0.81 | HSD11B1 (0.50) | KDM4EPOLBSMN1; SMN2ALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012042265-A1 | NOVEL ACRIDINE DERIVATIVES | PHARMINOX LIMITED (GB) | 2012-04-05 | — | — | WO | disclosed |