Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | PPIB | P23284 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037721 | 0.96 | SIGMAR1 (0.46) | SIGMAR1AVPR1AAKR1B1PPIB | |
| SCHEMBL9042535 | 0.88 | SIGMAR1 (0.47) | SIGMAR1AKR1B1KDM1A | |
| SCHEMBL9039447 | 0.84 | SIGMAR1 (0.46) | SIGMAR1KDM1A | |
| SCHEMBL9041706 | 0.82 | AVPR1A (0.56) | AVPR1AAKR1B1KDM1A | |
| SCHEMBL9037531 | 0.78 | AVPR1A (0.52) | AVPR1AAKR1B1KDM1A | |
| SCHEMBL9037851 | 0.76 | AKR1B1 (0.56) | AKR1B1RAB9A | |
| SCHEMBL9039746 | 0.73 | HCAR2 (0.54) | SIGMAR1AVPR1A | |
| SCHEMBL9039157 | 0.72 | AKR1B1 (0.53) | SIGMAR1AKR1B1RAB9A | |
| SCHEMBL6101688 | 0.70 | PGR (0.46) | AVPR1APPIB | |
| SCHEMBL16755703 | 0.70 | CYP3A4 (0.44) | AVPR1APPIBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5098925-A | Neurological disorders in mammals | ICI AMERICAS INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0441598-A2 | Spiroisoindole compounds | ZENECA INC. (US) | 1991-08-14 | — | — | EP | disclosed |