Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042535 | 0.96 | SIGMAR1 (0.47) | SIGMAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL9037721 | 0.88 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL9039874 | 0.84 | SIGMAR1 (0.47) | SIGMAR1KDM1A | |
| SCHEMBL9851214 | 0.83 | KDM1A (0.46) | SIGMAR1KDM1A | |
| SCHEMBL9039157 | 0.71 | AKR1B1 (0.53) | SIGMAR1 | |
| SCHEMBL28344489 | 0.71 | DRD2 (0.38) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL9039535 | 0.70 | AKR1B1 (0.46) | SIGMAR1 | |
| SCHEMBL9040302 | 0.69 | DRD1 (0.49) | SIGMAR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL9037531 | 0.69 | AVPR1A (0.52) | KDM1A | |
| SCHEMBL9037851 | 0.68 | AKR1B1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |