SCHEMBL6965449

SCHEMBL6965449

COC(=O)c1ccccc1COc1ccc(-c2cc(O)c(SCCc3ccccc3)c(=O)o2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.39
MAPT P10636 3/20 0.39
POLB P06746 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 3/20 0.38
MAOB P27338 2/20 0.38
MAOA P21397 1/20 0.38
ALDH1A1 P00352 1/20 0.38
FFAR1 O14842 2/20 0.38
FFAR4 Q5NUL3 2/20 0.38
LMNA P02545 1/20 0.38
HPGD P15428 1/20 0.38
TSHR P16473 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.38
MCL1 Q07820 1/20 0.37
ABCB1 P08183 1/20 0.37
HIF1A Q16665 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6952662 0.87 PTPN7 (0.47) MAPTPOLBSMN1; SMN2LMNAHPGD
SCHEMBL6963656 0.86 CYP1A1 (0.44) PTGER4MAPTFFAR1FFAR4ABCB1
SCHEMBL9039893 0.86 LMNA (0.43) MAPTPOLBSMN1; SMN2KDM4EALDH1A1
SCHEMBL6961069 0.86 MRGPRX4 (0.48) SMN1; SMN2KDM4EALDH1A1LMNAHPGD
SCHEMBL6952547 0.85 ABCB1 (0.50) MAPTMAOBFFAR1LMNAMCL1
SCHEMBL8534507 0.82 KDM4E (0.40) MAPTPOLBSMN1; SMN2KDM4EMAOB
SCHEMBL6956259 0.81 XDH (0.48) MAPTPOLBSMN1; SMN2ALDH1A1HPGD
SCHEMBL6956331 0.81 SLC16A3 (0.46) PTGER4MAPTMAOBMAOAFFAR1
SCHEMBL6958378 0.80 MAOA (0.45) MAOBMAOAFFAR1ABCB1
SCHEMBL6964784 0.80 L3MBTL1 (0.43) MAPTPOLBSMN1; SMN2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed