SCHEMBL9040225

SCHEMBL9040225

Cc1c(C(=O)O)ccc2c1OC(c1ccccc1)(c1ccccc1)O2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 10/20 0.42
HCAR3 P49019 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35
CYP1A2 P05177 1/20 0.35
ALDH1A1 P00352 2/20 0.34
ALOX15 P16050 1/20 0.34
MYC P01106 1/20 0.34
NOTUM Q6P988 1/20 0.34
SRD5A1 P18405 1/20 0.34
SRD5A2 P31213 1/20 0.34
WDR5 P61964 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4693418 0.86 CNR1 (0.39) CNR1SRD5A1SRD5A2
SCHEMBL4466643 0.82 CNR1 (0.44) CNR1ALDH1A1ALOX15SRD5A1SRD5A2
SCHEMBL4860502 0.80 ALOX5 (0.43) CNR1ALDH1A1ALOX15MYC
SCHEMBL8285530 0.78 CNR1 (0.44) CNR1HCAR3HCAR2ALDH1A1NOTUM
SCHEMBL10520286 0.78 ALDH1A1 (0.40) CYP1A2ALDH1A1MYCNOTUMTSHR
SCHEMBL3800470 0.76 CTNNB1 (0.37) CYP1A2ALDH1A1MYCTSHR
SCHEMBL6226020 0.75 CNR1 (0.64) CNR1ALDH1A1MYCSRD5A1SRD5A2
SCHEMBL9053044 0.74 GAA (0.36) CNR1CYP1A2ALDH1A1
SCHEMBL4696323 0.74 ALDH1A1 (0.48) CNR1ALDH1A1
SCHEMBL4481860 0.74 CNR1 (0.62) CNR1ALDH1A1MYCSRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0535192-B1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME HOFFMANN LA ROCHE (CH) 1996-06-19 EP disclosed
US-5486466-A ENZYME INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1996-01-23 US disclosed
US-5399741-A DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same HOFFMANN-LA ROCHE INC. (US) 1995-03-21 US disclosed
US-5294609-A Microbiocides HOFFMANN-LAROCHE INC. (US) 1994-03-15 US disclosed
EP-0535192-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. HOFFMANN LA ROCHE (CH) 1993-04-07 EP disclosed
WO-1992018490-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME F. HOFFMANN-LA ROCHE AG (CH) 1992-10-29 WO disclosed