Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.39 |
| ▸ | BRD4 | O60885 | 7/20 | 0.39 |
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9040225 | 0.86 | CNR1 (0.42) | CNR1SRD5A1SRD5A2 | |
| SCHEMBL4696323 | 0.78 | ALDH1A1 (0.48) | CNR1GAA | |
| SCHEMBL4694766 | 0.73 | CNR1 (0.56) | CNR1BRD4SRD5A1SRD5A2 | |
| SCHEMBL4466643 | 0.71 | CNR1 (0.44) | CNR1SRD5A1SRD5A2 | |
| SCHEMBL8285503 | 0.69 | TRPA1 (0.47) | CNR1GAA | |
| SCHEMBL4860502 | 0.69 | ALOX5 (0.43) | CNR1 | |
| SCHEMBL17424932 | 0.68 | BAZ2B (0.49) | PLK1 | |
| SCHEMBL8285530 | 0.68 | CNR1 (0.44) | CNR1SRD5A1SRD5A2 | |
| SCHEMBL5981399 | 0.68 | CNR1 (0.39) | CNR1 | |
| SCHEMBL20026810 | 0.67 | CNR1 (0.41) | CNR1SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532132-B1 | NOVEL BENZODIOXOLES | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | claimed |
| EP-1532132-B1 | NOVEL BENZODIOXOLES | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| EP-0535192-B1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | HOFFMANN LA ROCHE (CH) | 1996-06-19 | — | — | EP | disclosed |
| US-5486466-A | ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-01-23 | — | — | US | disclosed |
| US-5399741-A | DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5294609-A | Microbiocides | HOFFMANN-LAROCHE INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0535192-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. | HOFFMANN LA ROCHE (CH) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992018490-A1 | NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-29 | — | — | WO | disclosed |