Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429883 | 0.74 | CA2 (0.61) | RYR2PRKD1HSP90AA1PRKD2PRKD3 | |
| SCHEMBL12241446 | 0.71 | CDC7 (0.54) | PARP10PARP11PARP1CDC7DBF4 | |
| SCHEMBL7298799 | 0.70 | CA2 (0.45) | CA2 | |
| SCHEMBL8917048 | 0.69 | MEN1 (0.46) | PARP10PARP11PARP1CDK1MAPKAPK2 | |
| SCHEMBL8991845 | 0.68 | RYR2 (0.43) | RYR2PARP10PARP11PARP1PRKD1 | |
| SCHEMBL2600209 | 0.68 | RYR2 (0.66) | RYR2PARP10PARP11PARP1 | |
| SCHEMBL26942243 | 0.68 | PARP10 (0.54) | RYR2PARP10PARP11PARP1PRKD1 | |
| SCHEMBL8991820 | 0.68 | RYR2 (0.33) | RYR2PRKD1PRKD2PRKD3 | |
| SCHEMBL279791 | 0.67 | MEN1 (0.40) | PARP10PARP11PARP1CDC7DBF4 | |
| SCHEMBL9635286 | 0.66 | RYR2 (0.51) | RYR2PARP10PARP11PARP1PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0465254-B1 | Fused thiophene compounds and uses thereof | YOSHITOMI PHARMACEUTICAL (JP) | 1996-11-13 | — | — | EP | disclosed |
| US-5141930-A | Antianxietic drug, antipsychotics and cardiotonic agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0465254-A1 | Fused thiophene compounds and uses thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-01-08 | — | — | EP | disclosed |