Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903975 | 0.86 | GPR119 (0.56) | GPR119MAPTMEN1KMT2APOLB | |
| SCHEMBL904063 | 0.84 | GPR119 (0.66) | GPR119CHEK2NAMPTALDH1A1 | |
| SCHEMBL3372121 | 0.84 | GPR119 (0.58) | GPR119MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31731199 | 0.80 | GPR119 (0.49) | GPR119CHEK2NAMPTALDH1A1 | |
| SCHEMBL31216657 | 0.80 | GPR119 (0.51) | GPR119NAMPT | |
| SCHEMBL6114639 | 0.80 | GPR119 (0.51) | GPR119MEN1KMT2ANAMPT | |
| SCHEMBL27194426 | 0.80 | NAMPT (0.52) | GPR119NAMPT | |
| SCHEMBL25320725 | 0.79 | GPR119 (0.48) | GPR119MEN1KMT2ACHEK2NAMPT | |
| SCHEMBL10080587 | 0.76 | USP2 (0.66) | GPR119MAPTMEN1KMT2APOLB | |
| SCHEMBL31161469 | 0.76 | MGLL (0.53) | GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |