Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904041 | 0.80 | GPR119 (0.35) | GPR119KCNH2 | |
| SCHEMBL904073 | 0.72 | GPR119 (0.36) | GPR119GRM2 | |
| SCHEMBL10067592 | 0.72 | GPR119 (0.36) | GPR119GRM2 | |
| SCHEMBL904171 | 0.71 | GPR119 (0.41) | GPR119GRM2KCNH2 | |
| SCHEMBL903979 | 0.70 | MKNK1 (0.35) | GPR119 | |
| SCHEMBL904032 | 0.70 | ACACB (0.37) | GPR119GRM2 | |
| SCHEMBL10068006 | 0.69 | GPR119 (0.45) | GPR119 | |
| SCHEMBL10068007 | 0.67 | GPR119 (0.52) | GPR119 | |
| SCHEMBL904068 | 0.67 | GPR119 (0.46) | GPR119 | |
| SCHEMBL904187 | 0.66 | MKNK1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |