Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041363 | 0.77 | CYP1A2 (0.56) | ALDH1A1ACHE | |
| SCHEMBL9875385 | 0.77 | KDM4E (0.54) | KDM4EKMT2AGAAHSD17B10ALDH1A1 | |
| SCHEMBL9875611 | 0.72 | BCHE (0.53) | KDM4EALDH1A1BCHEACHE | |
| SCHEMBL9040732 | 0.71 | KDM4E (0.51) | KDM4EKMT2AALDH1A1HPGDBCHE | |
| SCHEMBL9874947 | 0.71 | KDM4E (0.51) | KDM4EKMT2ABCHEACHEHTT | |
| SCHEMBL8984077 | 0.71 | KMT2A (0.67) | KDM4EKMT2APOLBBCHEACHE | |
| SCHEMBL9874867 | 0.70 | PABPC1 (0.71) | KMT2APOLBBCHEACHENPC1 | |
| SCHEMBL9875231 | 0.69 | BCHE (0.64) | KDM4EKMT2ABCHEACHEHTT | |
| SCHEMBL9875000 | 0.69 | KDM4E (0.57) | KDM4EKMT2APOLBBCHEACHE | |
| SCHEMBL9874160 | 0.68 | BCHE (0.54) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430114-B1 | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5112829-A | Intermediates for Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0430114-A2 | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-06-05 | — | — | EP | disclosed |
| US-4994452-A | Memory disfunction | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-19 | — | — | US | disclosed |