Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042310 | 0.84 | KDM4C (0.43) | LMNAMAPK8ALDH1A1KDM4ETSHR | |
| SCHEMBL9043059 | 0.82 | MAPK8 (0.53) | LMNAMAPK8ALDH1A1KDM4ETSHR | |
| SCHEMBL9041922 | 0.78 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTHTTCDK1 | |
| SCHEMBL25886396 | 0.75 | ADORA2A (0.40) | LMNAALDH1A1ADORA2AADORA2BSMN1; SMN2 | |
| SCHEMBL9040334 | 0.74 | KDM4E (0.67) | LMNAALDH1A1KDM4ETSHRBLM | |
| SCHEMBL9041780 | 0.73 | BRD9 (0.40) | LMNAALDH1A1KDM4ETSHRBLM | |
| SCHEMBL9042400 | 0.73 | MAPK8 (0.44) | MAPK8CDK5ADORA2AADORA2BPDPK1 | |
| SCHEMBL1967294 | 0.73 | LMNA (0.49) | LMNAPDGFRACDK5TYRO3ALDH1A1 | |
| SCHEMBL29122205 | 0.73 | ADORA2A (0.38) | LMNAMAPK8ADORA2AADORA2BSMN1; SMN2 | |
| SCHEMBL11753420 | 0.71 | AKR1B1 (0.54) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613470-B1 | NOVEL 4-CINNOLINONE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY | PF MEDICAMENT (FR) | 1996-01-10 | — | — | EP | claimed |