Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042400 | 0.88 | MAPK8 (0.44) | MAPK8MAPK9MAPK10CSF1RPIM1 | |
| SCHEMBL9042310 | 0.84 | KDM4C (0.43) | MAPK8KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9042883 | 0.82 | LMNA (0.42) | MAPK8KDM4EALDH1A1TSHRLMNA | |
| SCHEMBL9041922 | 0.78 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL24182151 | 0.76 | ADORA2A (0.62) | MAPK8MAPK9MAPK10MAP4K4CSF1R | |
| SCHEMBL9040334 | 0.74 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9041780 | 0.73 | BRD9 (0.40) | PIM1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11154817 | 0.73 | MAPK8 (0.47) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL16440327 | 0.72 | MAPK8 (0.42) | MAPK8MAPK9MAPK10KDM4EALDH1A1 | |
| SCHEMBL3247322 | 0.71 | AKR1B1 (0.57) | MAPK8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613470-B1 | NOVEL 4-CINNOLINONE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY | PF MEDICAMENT (FR) | 1996-01-10 | — | — | EP | claimed |