Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FGB | P02675 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29032652 | 0.73 | TUBB4A (0.47) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL9404866 | 0.72 | LMNA (0.47) | MAPTLMNAPDE4APDE4BPDE4C | |
| SCHEMBL11486215 | 0.68 | EZH2 (0.47) | PDE4APDE4BPDE4CPDE4DDDB1 | |
| SCHEMBL8248998 | 0.67 | DDB1 (0.59) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11486292 | 0.67 | GRM5 (0.46) | LMNAALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31134765 | 0.66 | GRM5 (0.60) | PDE4APDE4DMEN1KMT2ACYP3A4 | |
| SCHEMBL6326889 | 0.66 | GRM5 (0.48) | LMNAPOLBKMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL16495324 | 0.65 | DDB1 (0.49) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10877473 | 0.65 | ACHE (0.53) | ALDH1A1POLBMEN1RAB9AKMT2A | |
| SCHEMBL32691557 | 0.65 | GRM5 (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471358-B1 | Fluoroethylcamptothecin derivatives | KYORIN SEIYAKU KK (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0471358-A1 | Fluoroethylcamptothecin derivatives | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-02-19 | — | — | EP | disclosed |