Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FGB | P02675 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404793 | 0.82 | NOTUM (0.42) | MAPTNOTUMPOLBMEN1KMT2A | |
| SCHEMBL9404923 | 0.72 | KMT2A (0.45) | ALDH1A1MEN1RAB9AKMT2AMAOB | |
| SCHEMBL9042960 | 0.72 | MAPT (0.43) | LMNAMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9404807 | 0.71 | ALDH1A1 (0.73) | LMNAMAPTALDH1A1KDM4EGLA | |
| SCHEMBL21232729 | 0.70 | NOTUM (0.63) | LMNANOTUMALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL9041741 | 0.69 | ALDH1A1 (0.59) | LMNAMAPTALDH1A1KDM4EGLA | |
| Hydrochloric Acid SCHEMBL9404913 | 0.68 | ALDH1A1 (0.57) | LMNAMAPTALDH1A1KDM4EGLA | |
| SCHEMBL6273537 | 0.68 | NOTUM (0.57) | LMNAMAPTNOTUMALDH1A1KDM4E | |
| SCHEMBL29187823 | 0.68 | NOTUM (0.47) | LMNAMAPTNOTUMALDH1A1KDM4E | |
| SCHEMBL10689221 | 0.65 | NOTUM (0.41) | LMNAMAPTNOTUMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |