Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL86330 | 0.88 | TDP1 (0.59) | TDP1L3MBTL1AKR1B1ACHEMAPK14 | |
| SCHEMBL7243476 | 0.84 | ALDH1A1 (0.54) | TDP1L3MBTL1AKR1B1ACHEMAPK14 | |
| SCHEMBL31123671 | 0.81 | ACHE (0.59) | TDP1L3MBTL1AKR1B1ACHEMAPK14 | |
| SCHEMBL86279 | 0.81 | ACHE (0.59) | TDP1L3MBTL1AKR1B1ACHEMAPK14 | |
| SCHEMBL31510701 | 0.81 | ACHE (0.59) | TDP1L3MBTL1AKR1B1ACHEMAPK14 | |
| SCHEMBL91640 | 0.81 | VHL (0.51) | L3MBTL1AKR1B1ACHEMAPK14HSD17B3 | |
| SCHEMBL85994 | 0.81 | AKR1B1 (0.49) | AKR1B1ACHEMAPK14HSD17B3MAOA | |
| SCHEMBL11873711 | 0.81 | ELANE (0.51) | TDP1AKR1B1ACHEMAPK14HSD17B3 | |
| SCHEMBL86390 | 0.81 | AKR1B1 (0.49) | TDP1L3MBTL1AKR1B1ACHEMAPK14 | |
| SCHEMBL11481280 | 0.78 | MAPT (0.57) | TDP1L3MBTL1AKR1B1ACHEMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345747-B1 | Tricyclic compounds | KYOWA HAKKO KOGYO KK (JP) | 1996-06-26 | — | — | EP | disclosed |
| EP-0312051-B1 | Tricyclic compounds | KYOWA HAKKO KOGYO KK (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5302596-A | DIBENZO-CYCLOHEPTENES,-OXEPINS AND-THIEPINS SUBSTITUTED BY A HETEROCYCLO-ALKYL | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-04-12 | — | — | US | disclosed |
| US-5242931-A | Antiischemic agents and cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5118701-A | Antiischemic agents, anticoagulants | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-5010087-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-04-23 | — | — | US | disclosed |
| US-5010104-A | Antiischemic agent, cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-04-23 | — | — | US | disclosed |
| US-4999363-A | Inhibit biosynthesis of thromboxane A2 | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-03-12 | — | — | US | disclosed |
| EP-0345747-A2 | Tricyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-13 | — | — | EP | disclosed |
| US-4882351-A | CARDIOVASCULAR DISORDERS; | ROUSSEL UCLAF (FR) | 1989-11-21 | — | — | US | disclosed |
| EP-0312051-A2 | Tricyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-04-19 | — | — | EP | disclosed |