Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044255 | 0.91 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9045052 | 0.87 | MEN1 (0.55) | ALDH1A1MEN1KMT2AMAPTEDNRA | |
| SCHEMBL9046709 | 0.83 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AHSD11B1MAPT | |
| SCHEMBL9046700 | 0.83 | EDNRA (0.49) | ALDH1A1MEN1KMT2AMAPTEDNRA | |
| SCHEMBL9047567 | 0.82 | EDNRA (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9045149 | 0.81 | NPSR1 (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9043635 | 0.81 | EDNRA (0.69) | EDNRA | |
| SCHEMBL6785011 | 0.80 | EDNRA (0.67) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9493604 | 0.80 | EDNRA (0.51) | ALDH1A1MEN1KMT2AMAPTEDNRA | |
| SCHEMBL9047803 | 0.79 | PKM (0.55) | ALDH1A1MEN1KMT2AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |