Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | HEXA | P06865 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31504610 | 0.84 | L3MBTL1 (0.54) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL11864905 | 0.81 | CYP1A2 (0.57) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL3425540 | 0.78 | LMNA (0.48) | MAPTCYP1A2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL12496122 | 0.77 | NPC1 (0.59) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL7699598 | 0.77 | KDM4E (0.49) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL9044409 | 0.75 | ALDH1A1 (0.55) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL16117348 | 0.74 | NPC1 (0.56) | CYP1A2ALDH1A1KDM4EHTR2AHTR2B | |
| SCHEMBL3561069 | 0.72 | LMNA (0.47) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL4063214 | 0.71 | MAPT (0.47) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL1573080 | 0.71 | KDM4E (0.49) | MAPTCYP1A2ALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |