Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 15/20 | 0.66 |
| ▸ | DRD2 | P14416 | 5/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 7/20 | 0.61 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | DRD5 | P21918 | 3/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29525355 | 0.87 | DRD2 (0.67) | DRD2DRD4DRD3 | |
| SCHEMBL7607969 | 0.86 | HTR7 (0.68) | HTR7DRD2DRD4HTR1ADRD3 | |
| SCHEMBL9096389 | 0.81 | DRD2 (0.83) | HTR7DRD2DRD4HTR1ADRD3 | |
| SCHEMBL31419459 | 0.80 | HDAC1 (0.49) | HTR7DRD2DRD4HTR1ADRD3 | |
| SCHEMBL26621465 | 0.80 | HDAC1 (0.49) | HTR7DRD2DRD4HTR1ADRD3 | |
| SCHEMBL26750446 | 0.80 | KDM4E (0.52) | HTR7DRD2DRD4HTR1ADRD3 | |
| Hydrochloric Acid SCHEMBL9096256 | 0.80 | DRD2 (0.81) | HTR7DRD2DRD4HTR1ADRD3 | |
| SCHEMBL15681627 | 0.77 | HDAC1 (0.54) | DRD2DRD4DRD3 | |
| SCHEMBL9096608 | 0.77 | DRD2 (0.80) | HTR7DRD2DRD4HTR1ADRD3 | |
| SCHEMBL27071702 | 0.77 | ALDH1A1 (0.47) | HTR7DRD2DRD4HTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445781-B1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0445781-A1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-5013837-A | Treatment of glaucoma | STERLING DRUG INC. (US) | 1991-05-07 | — | — | US | disclosed |
| US-4973587-A | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method | STERLING DRUG INC. (US) | 1990-11-27 | — | — | US | disclosed |