Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9046804 | 0.80 | TAS1R3 (0.38) | LMNAHPGDP2RX7POLBGAA | |
| Bicarbonate SCHEMBL7624086 | 0.78 | HPGD (0.56) | LMNAHPGDCCR2HTTPOLB | |
| Bicarbonate SCHEMBL7620865 | 0.74 | GAA (0.52) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7615143 | 0.73 | LMNA (0.47) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7621065 | 0.72 | ALPL (0.47) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7620489 | 0.72 | LMNA (0.46) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7615547 | 0.72 | LMNA (0.43) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL7614529 | 0.72 | LMNA (0.45) | LMNAHPGDP2RX7NPC1RAB9A | |
| Bicarbonate SCHEMBL9043289 | 0.71 | KMT2A (0.57) | P2RX7RAB9AHTTPOLBGAA | |
| Bicarbonate SCHEMBL7615733 | 0.71 | LMNA (0.44) | LMNAHPGDNPC1RAB9APSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706527-A1 | SUBSTITUTED SPIROHETEROCYCLIC 1H-3-ARYLPYRROLIDINE-2,4-DIONE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS PEST-CONTROL AGENTS | BAYER AG (DE) | 1996-04-17 | — | — | EP | disclosed |