Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046179 | 0.80 | MAPT (0.50) | MAPTALDH1A1TDP1HPGDALOX12 | |
| SCHEMBL10447212 | 0.76 | DRD2 (0.39) | DRD2MAPTALDH1A1TDP1HPGD | |
| SCHEMBL10526592 | 0.75 | TBXA2R (0.52) | MAPTALDH1A1TDP1HPGDALOX12 | |
| SCHEMBL9046208 | 0.74 | ALDH1A1 (0.47) | MAPTALDH1A1TDP1HPGDALOX12 | |
| SCHEMBL16385821 | 0.73 | DRD2 (0.39) | DRD2MAPTALDH1A1TDP1HPGD | |
| SCHEMBL10444683 | 0.73 | DRD2 (0.37) | DRD2MAPTALDH1A1TDP1HPGD | |
| SCHEMBL10446740 | 0.70 | DRD2 (0.37) | DRD2MAPTALDH1A1TDP1HPGD | |
| SCHEMBL11463305 | 0.67 | HSD17B3 (0.48) | MAPTALDH1A1TDP1HPGDALOX12 | |
| SCHEMBL7526606 | 0.66 | ALDH1A1 (0.50) | DRD2MAPTALDH1A1TDP1HPGD | |
| SCHEMBL23546244 | 0.66 | ALDH1A1 (0.62) | DRD2MAPTALDH1A1TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345747-B1 | Tricyclic compounds | KYOWA HAKKO KOGYO KK (JP) | 1996-06-26 | — | — | EP | disclosed |
| EP-0312051-B1 | Tricyclic compounds | KYOWA HAKKO KOGYO KK (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5302596-A | DIBENZO-CYCLOHEPTENES,-OXEPINS AND-THIEPINS SUBSTITUTED BY A HETEROCYCLO-ALKYL | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-04-12 | — | — | US | disclosed |
| US-5118701-A | Antiischemic agents, anticoagulants | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-5010087-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-04-23 | — | — | US | disclosed |
| US-5010104-A | Antiischemic agent, cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-04-23 | — | — | US | disclosed |
| US-4999363-A | Inhibit biosynthesis of thromboxane A2 | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-03-12 | — | — | US | disclosed |
| EP-0345747-A2 | Tricyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-13 | — | — | EP | disclosed |
| US-4882351-A | CARDIOVASCULAR DISORDERS; | ROUSSEL UCLAF (FR) | 1989-11-21 | — | — | US | disclosed |
| EP-0312051-A2 | Tricyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-04-19 | — | — | EP | disclosed |