Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1455251 | 0.78 | ALDH1A1 (0.41) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL1455249 | 0.78 | ALDH1A1 (0.41) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL113257 | 0.73 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL155459 | 0.73 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL3293153 | 0.73 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL3293150 | 0.73 | MAPT (0.46) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL11630171 | 0.70 | ESR1 (0.35) | KMT2AALDH1A1L3MBTL1LMNAHPGD | |
| SCHEMBL766244 | 0.69 | LMNA (0.33) | KMT2ALMNA | |
| SCHEMBL14661199 | 0.68 | PPARA (0.36) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL25968943 | 0.67 | ALDH1A1 (0.50) | MAPTKMT2AALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006551-A2 | NEUROPROTECTIVE MOLECULES AND METHODS OF TREATING NEUROLOGICAL DISORDERS AND INDUCING STRESS GRANULES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-01-12 | — | — | WO | disclosed |