Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045484 | 0.84 | CYP4A11 (0.45) | RAB9AYTHDC1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9045449 | 0.83 | YTHDC1 (0.39) | RAB9AYTHDC1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9045252 | 0.83 | MAPT (0.39) | YTHDC1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9046639 | 0.74 | EP300 (0.40) | YTHDC1MEN1KMT2ATP53EP300 | |
| SCHEMBL9471023 | 0.73 | KMT2A (0.43) | GAARAB9ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9045926 | 0.70 | YTHDC1 (0.45) | RAB9AYTHDC1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12537305 | 0.69 | YTHDC1 (0.64) | YTHDC1CYP4A11EP300 | |
| SCHEMBL9045967 | 0.68 | SMN1; SMN2 (0.39) | RAB9AMAPTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2881295 | 0.68 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C9CYP2C19CYP4A11 | |
| SCHEMBL9045704 | 0.68 | HSP90AA1 (0.45) | GAARAB9ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |
| US-4996206-A | Antitumor agent | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-02-26 | — | — | US | disclosed |