Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 4/20 | 0.45 |
| ▸ | EP300 | Q09472 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045154 | 0.79 | MAPT (0.33) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9046199 | 0.77 | ELANE (0.36) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9345121 | 0.77 | CNOT7 (0.35) | ALDH1A1LMNA | |
| SCHEMBL9045484 | 0.72 | CYP4A11 (0.45) | YTHDC1EP300CYP11B2NPC1RAB9A | |
| SCHEMBL9045252 | 0.71 | MAPT (0.39) | YTHDC1EP300CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL9045449 | 0.71 | YTHDC1 (0.39) | YTHDC1EP300CYP11B2NPC1RAB9A | |
| SCHEMBL9045295 | 0.70 | GAA (0.43) | YTHDC1EP300RAB9ACYP1A2CYP3A4 | |
| SCHEMBL9776223 | 0.70 | MAPT (0.38) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9776047 | 0.69 | NPC1 (0.37) | NPC1RAB9ACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL9046356 | 0.67 | PTPN11 (0.33) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |