Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045295 | 0.84 | GAA (0.43) | CYP4A11SMN1; SMN2ALDH1A1CYP4F2YTHDC1 | |
| SCHEMBL9045704 | 0.84 | HSP90AA1 (0.45) | CYP1A2CYP3A4CYP2C9CYP2C19TP53 | |
| SCHEMBL9045252 | 0.78 | MAPT (0.39) | CYP4A11SMN1; SMN2ALDH1A1CYP4F2YTHDC1 | |
| SCHEMBL9045449 | 0.78 | YTHDC1 (0.39) | CYP4A11SMN1; SMN2ALDH1A1CYP4F2YTHDC1 | |
| SCHEMBL9046201 | 0.78 | TAS1R3 (0.41) | ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL9045157 | 0.72 | PTPN11 (0.40) | ALDH1A1CYP1A2CYP2C9CYP2C19HPGD | |
| SCHEMBL70185 | 0.70 | CYP4A11 (0.75) | CYP4A11SMN1; SMN2ALDH1A1CYP4F2CYP1A2 | |
| SCHEMBL12537305 | 0.70 | YTHDC1 (0.64) | CYP4A11YTHDC1EP300 | |
| SCHEMBL2881295 | 0.68 | CYP1A2 (0.54) | CYP4A11SMN1; SMN2ALDH1A1CYP4F2CYP1A2 | |
| SCHEMBL7978843 | 0.68 | CYP4A11 (0.62) | CYP4A11SMN1; SMN2ALDH1A1CYP4F2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| CN-1030608-C | N-(pyrrolo {2,3-d} pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-01-03 | — | — | CN | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |
| US-4996206-A | Antitumor agent | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-02-26 | — | — | US | disclosed |