Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042445 | 0.86 | LMNA (0.42) | MEN1KMT2AALDH1A1CASP3LMNA | |
| SCHEMBL9041633 | 0.83 | SMN1; SMN2 (0.49) | KDM4EGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL9043025 | 0.81 | ALDH1A1 (0.55) | KDM4ECYP19A1GRM2GAAMEN1 | |
| SCHEMBL9042389 | 0.81 | ALDH1A1 (0.47) | KDM4EGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL9043162 | 0.79 | SMN1; SMN2 (0.48) | KDM4EGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL9042485 | 0.77 | ALDH1A1 (0.46) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9043948 | 0.75 | KMT2A (0.47) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9044339 | 0.71 | ALDH1A1 (0.41) | KDM4EGRM2MEN1KMT2AALDH1A1 | |
| SCHEMBL23918548 | 0.68 | KMT2A (0.56) | KDM4EGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL1832087 | 0.68 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1CASP3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | claimed |