Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043612 | 0.86 | POLB (0.46) | ALDH1A1KMT2AHTTSMN1; SMN2CYP2C9 | |
| SCHEMBL9044246 | 0.82 | HTT (0.42) | ALDH1A1KDM4EMEN1KMT2AHDAC1 | |
| SCHEMBL9043025 | 0.81 | ALDH1A1 (0.55) | ALDH1A1GRM2KDM4EMEN1KMT2A | |
| SCHEMBL9042078 | 0.79 | GRM5 (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL9042862 | 0.76 | L3MBTL1 (0.50) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7462557 | 0.73 | ALDH1A1 (0.71) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9043663 | 0.71 | L3MBTL1 (0.46) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11492920 | 0.71 | FKBP1A (0.48) | ALDH1A1MEN1KMT2ASMN1; SMN2CYP2C9 | |
| SCHEMBL9045382 | 0.71 | KDM4E (0.39) | ALDH1A1GRM2KDM4EMEN1KMT2A | |
| SCHEMBL14829141 | 0.71 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | claimed |