Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043805 | 0.94 | EDNRA (0.49) | KITEDNRAKDM4EEDNRBMEN1 | |
| SCHEMBL9493604 | 0.89 | EDNRA (0.51) | KITEDNRAEDNRBMEN1ALDH1A1 | |
| SCHEMBL9045052 | 0.88 | MEN1 (0.55) | EDNRAEDNRBMEN1ALDH1A1MAPT | |
| SCHEMBL9046709 | 0.84 | ALDH1A1 (0.60) | KITEDNRAEDNRBMEN1ALDH1A1 | |
| SCHEMBL9045118 | 0.83 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL7974338 | 0.82 | EDNRA (0.41) | EDNRAEDNRBMEN1ALDH1A1MAPT | |
| SCHEMBL9045149 | 0.82 | NPSR1 (0.51) | KITEDNRAKDM4EEDNRBMEN1 | |
| SCHEMBL9046700 | 0.81 | EDNRA (0.49) | KITEDNRAEDNRBMEN1ALDH1A1 | |
| SCHEMBL9047567 | 0.80 | EDNRA (0.51) | KITEDNRAKDM4EEDNRBMEN1 | |
| SCHEMBL6785011 | 0.80 | EDNRA (0.67) | EDNRAKDM4EEDNRBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |