Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044020 | 0.96 | EDNRA (0.42) | EDNRAPKMALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL9491423 | 0.91 | EDNRA (0.43) | EDNRAPKMALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL9047803 | 0.83 | PKM (0.55) | EDNRAPKMALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL9045446 | 0.82 | KIT (0.48) | EDNRAALDH1A1EDNRBMEN1MAPT | |
| SCHEMBL9043342 | 0.79 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL9044797 | 0.79 | RXFP1 (0.54) | RXFP1 | |
| SCHEMBL9043805 | 0.78 | EDNRA (0.49) | EDNRAALDH1A1EDNRBMEN1MAPT | |
| SCHEMBL9045052 | 0.77 | MEN1 (0.55) | EDNRAALDH1A1EDNRBMEN1MAPT | |
| SCHEMBL14289222 | 0.77 | EDNRA (0.42) | EDNRAALDH1A1EDNRBMEN1MAPT | |
| SCHEMBL9043154 | 0.77 | ALDH1A1 (0.44) | EDNRAPKMALDH1A1RXFP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081335-A1 | PYRIMIDINE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |