Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9776186 | 0.89 | L3MBTL1 (0.32) | MAPK14L3MBTL1ITGB1ITGA4ALDH1A1 | |
| SCHEMBL9046156 | 0.83 | TAS1R3 (0.37) | MAPK14L3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL9046356 | 0.82 | PTPN11 (0.33) | ALDH1A1KDM4EHPGDHSD17B10GAA | |
| SCHEMBL9471289 | 0.80 | MAPK14 (0.37) | MAPK14L3MBTL1ITGB1ITGA4ALDH1A1 | |
| SCHEMBL9044791 | 0.80 | L3MBTL1 (0.33) | L3MBTL1RAB9A | |
| SCHEMBL9046699 | 0.80 | USP2 (0.34) | GAA | |
| SCHEMBL9044170 | 0.79 | CYP26A1 (0.36) | MAPK14L3MBTL1ITGB1ITGA4ALDH1A1 | |
| SCHEMBL9047678 | 0.79 | MAPK14 (0.34) | MAPK14L3MBTL1ITGB1ITGA4ALDH1A1 | |
| SCHEMBL9045924 | 0.78 | MAPT (0.33) | — | |
| SCHEMBL9046580 | 0.78 | ELANE (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |