Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 10/20 | 0.48 |
| ▸ | CNR2 | P34972 | 10/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086693 | 0.86 | MEN1 (0.66) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL89655 | 0.85 | MEN1 (0.68) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL90468 | 0.83 | KMT2A (0.50) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL89358 | 0.80 | MEN1 (0.68) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL89024 | 0.80 | MEN1 (0.47) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL89739 | 0.77 | ALDH1A1 (0.47) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL8236725 | 0.74 | MEN1 (0.59) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL2470064 | 0.73 | MEN1 (0.84) | POLBMEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL89084 | 0.72 | KMT2A (0.44) | POLBMEN1KMT2ACNR1CNR2 | |
| SCHEMBL1070915 | 0.71 | MEN1 (0.48) | POLBMEN1KMT2ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | POLB 589/4885MEN1 2336/4885KMT2A 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.