Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 13/20 | 0.51 |
| ▸ | HTR2C | P28335 | 13/20 | 0.51 |
| ▸ | HTR2B | P41595 | 13/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045792 | 0.95 | L3MBTL1 (0.53) | L3MBTL1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL8828131 | 0.90 | CYP3A4 (0.52) | KDM4EALDH1A1HPGDGAAOPRM1 | |
| SCHEMBL9468388 | 0.88 | KDM4E (0.50) | L3MBTL1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL8828277 | 0.88 | KDM4E (0.66) | L3MBTL1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL8828235 | 0.85 | MAPT (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2OPRM1 | |
| SCHEMBL8828147 | 0.85 | MAPT (0.56) | ALDH1A1HPGDGAAOPRM1 | |
| SCHEMBL8828659 | 0.84 | CDK8 (0.49) | KDM4EALDH1A1HPGDGAAOPRM1 | |
| SCHEMBL8828272 | 0.84 | OPRM1 (0.47) | ALDH1A1HPGDGAAOPRM1OPRK1 | |
| SCHEMBL8828188 | 0.84 | LMNA (0.49) | ALDH1A1GAASMN1; SMN2OPRM1 | |
| SCHEMBL8828274 | 0.84 | OPRM1 (0.49) | KDM4EALDH1A1HPGDGAAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | claimed |
| EP-0711287-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 1996-08-28 | — | — | EP | claimed |
| EP-0711287-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1996-05-15 | — | — | EP | claimed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | claimed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | claimed |
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |