Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045021 | 0.78 | MEN1 (0.48) | MEN1KMT2AHTR7POLBSIGMAR1 | |
| SCHEMBL9046152 | 0.77 | SIGMAR1 (0.42) | MEN1KMT2APOLBSIGMAR1DRD4 | |
| SCHEMBL11491907 | 0.73 | PNMT (0.52) | KMT2ASIGMAR1DRD4ALDH1A1NPSR1 | |
| SCHEMBL6829563 | 0.72 | KMT2A (0.47) | MEN1KMT2AHTR7POLBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL11487665 | 0.72 | PNMT (0.51) | SIGMAR1DRD4ALDH1A1NPSR1 | |
| SCHEMBL2396688 | 0.70 | HTR1A (0.57) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11491923 | 0.70 | PNMT (0.52) | KMT2ASIGMAR1DRD4 | |
| SCHEMBL2828437 | 0.69 | C5AR1 (0.52) | MEN1KMT2ASIGMAR1DRD4ACHE | |
| SCHEMBL172809 | 0.68 | C5AR1 (0.51) | KMT2AHTR7SIGMAR1DRD4ALDH1A1 | |
| SCHEMBL2977789 | 0.68 | MEN1 (0.64) | MEN1KMT2APOLBSIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372776-B1 | Arylpiperidine derivatives | PFIZER (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5294619-A | N-(nitrogen-containing heterocyclylalkyl-phenyl-piperidines | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5153206-A | Neuroleptic agents for treating psychological disorders | PFIZER INC. (US) | 1992-10-06 | — | — | US | disclosed |
| WO-1990006303-A1 | ARYLPIPERIDINE DERIVATIVES | PFIZER INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| EP-0372776-A2 | Arylpiperidine derivatives | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |