Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048746 | 0.86 | ALDH1A1 (0.56) | MAPTALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL9049433 | 0.78 | MAPT (0.39) | MAPTALDH1A1POLBNPC1RAB9A | |
| SCHEMBL9046694 | 0.76 | ALDH1A1 (0.40) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL7680556 | 0.76 | MAPT (0.43) | MAPTALDH1A1POLBNPC1RAB9A | |
| SCHEMBL19575607 | 0.75 | NPC1 (0.44) | SYKRETCCNB2CDK1CCNB1 | |
| SCHEMBL9045452 | 0.70 | CRHR1 (0.51) | — | |
| SCHEMBL2504479 | 0.66 | SYK (0.46) | SYKPOLBNPC1RAB9APKM | |
| SCHEMBL91473 | 0.66 | NPSR1 (0.49) | MAPTALDH1A1NPC1RAB9APKM | |
| SCHEMBL5922920 | 0.66 | KMT2A (0.41) | MAPTALDH1A1SYKPOLBRET | |
| SCHEMBL19575357 | 0.66 | RET (0.55) | MAPTPOLBRETNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |