Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048746 | 0.85 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL9047601 | 0.78 | MAPT (0.41) | MAPTALDH1A1RAB9ANPC1SORT1 | |
| SCHEMBL9046694 | 0.72 | ALDH1A1 (0.40) | MAPTALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL27889608 | 0.72 | TRPV1 (0.44) | MAPTALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL20918900 | 0.68 | SKP2 (0.46) | MAPTALDH1A1CNR1CNR2NCEH1 | |
| SCHEMBL21677170 | 0.67 | CNR1 (0.48) | CNR1CNR2NCEH1POLBCTDSP1 | |
| SCHEMBL10456934 | 0.67 | NOS3 (0.39) | ALDH1A1RAB9ANPC1LMNACNR1 | |
| SCHEMBL27906206 | 0.67 | MAPT (0.42) | MAPTALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL9047853 | 0.67 | CRHR1 (0.46) | MAPK1 | |
| SCHEMBL9047025 | 0.66 | CRHR1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |