Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048880 | 0.82 | ALOX5 (0.52) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9049066 | 0.80 | ALOX5 (0.47) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9049626 | 0.77 | ALOX5 (0.45) | ALOX5LMNAKMT2AEPHX2ACACB | |
| SCHEMBL9367947 | 0.75 | ALOX5 (0.44) | ALOX5KMT2AEPHX2ACACBACACA | |
| SCHEMBL9047247 | 0.73 | ALOX5 (0.46) | ALOX5MAOAMAOBEPHX2ACACB | |
| SCHEMBL9048632 | 0.72 | ALOX5 (0.69) | ALOX5LMNACYP3A4TSHRALDH1A1 | |
| SCHEMBL9048674 | 0.71 | ALOX5 (0.71) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9048865 | 0.71 | ALOX5 (0.49) | ALOX5EPHX2 | |
| SCHEMBL11731546 | 0.69 | PYCR1 (0.51) | LMNAPYCR1USP2CYP3A4TSHR | |
| SCHEMBL9048294 | 0.68 | ALOX5 (0.66) | ALOX5EPHX2ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | claimed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |