Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 3/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094940 | 0.82 | PIM1 (0.48) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL8320413 | 0.82 | LMNA (0.41) | PIM1GSK3AGSK3BPIM3TOP2A | |
| SCHEMBL9673380 | 0.80 | STAT3 (0.44) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL12835792 | 0.73 | STAT3 (0.42) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9694397 | 0.72 | PIM1 (0.43) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL15789762 | 0.72 | ALDH1A1 (0.52) | PIM1GSK3AGSK3BPIM3KDM4E | |
| SCHEMBL9242205 | 0.72 | ALDH1A1 (0.52) | PIM1GSK3AGSK3BPIM3KDM4E | |
| SCHEMBL9782871 | 0.72 | STAT3 (0.39) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL12835798 | 0.71 | STAT3 (0.35) | PIM1GSK3AGSK3BPIM3CSNK1G1 | |
| SCHEMBL9568366 | 0.71 | MAPT (0.40) | KDM4EALDH1A1POLBTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |