Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 6/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 6/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.42 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049638 | 0.78 | MAOB (0.56) | — | |
| SCHEMBL9097905 | 0.70 | DRD2 (0.62) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL23339326 | 0.69 | HTR7 (0.63) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL15396975 | 0.69 | HTR7 (0.63) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL27675343 | 0.69 | ALDH1A1 (0.46) | HTR7BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL27675339 | 0.68 | CNR1 (0.44) | HTR7BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL27655367 | 0.68 | CNR1 (0.44) | HTR7BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2491730 | 0.68 | HTR7 (0.62) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL17049383 | 0.67 | MGLL (0.50) | HTR7HTR1ADRD2DRD3CYP1A2 | |
| SCHEMBL15301093 | 0.67 | MGLL (0.50) | HTR7HTR1ADRD2DRD3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |