Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039441 | 0.92 | LMNA (0.52) | LMNAPOLBDRD4DRD2DRD3 | |
| SCHEMBL9050813 | 0.90 | ADRA1D (0.45) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL8861906 | 0.85 | SIGMAR1 (0.51) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL9050818 | 0.81 | KMT2A (0.44) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL9050202 | 0.81 | SIGMAR1 (0.55) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL9047699 | 0.79 | LMNA (0.48) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL8861887 | 0.78 | AKT2 (0.44) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL8861853 | 0.78 | SIGMAR1 (0.55) | LMNAPOLBSIGMAR1DRD4DRD2 | |
| SCHEMBL8861925 | 0.77 | SIGMAR1 (0.60) | SIGMAR1DRD4DRD2DRD3GAA | |
| SCHEMBL8861841 | 0.76 | KMT2A (0.52) | LMNADRD4DRD2DRD3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730582-A1 | ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | claimed |
| WO-1995014672-A1 | ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | claimed |
| EP-0730582-A1 | ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014672-A1 | ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |