Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048831 | 0.90 | LMNA (0.48) | MC4RDRD2DRD4DRD3LMNA | |
| SCHEMBL9039441 | 0.83 | LMNA (0.52) | DRD2DRD4DRD3LMNAPOLB | |
| SCHEMBL9050212 | 0.82 | DRD4 (0.50) | MC4RCCR3DRD2DRD4DRD3 | |
| SCHEMBL9050818 | 0.77 | KMT2A (0.44) | MC4RDRD2DRD4DRD3LMNA | |
| SCHEMBL8861838 | 0.77 | DRD4 (0.49) | CCR3DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL8861906 | 0.76 | SIGMAR1 (0.51) | MC4RDRD2DRD4DRD3LMNA | |
| Oxalic Acid SCHEMBL8861898 | 0.74 | KDM4E (0.48) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL9047699 | 0.73 | LMNA (0.48) | MC4RDRD2DRD4DRD3LMNA | |
| SCHEMBL9050202 | 0.72 | SIGMAR1 (0.55) | MC4RDRD2DRD4DRD3LMNA | |
| Hydrochloric Acid SCHEMBL8963938 | 0.70 | DRD2 (0.58) | MC4RCCR3DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730582-A1 | ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014672-A1 | ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |