Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154329 | 0.96 | KMT2A (0.31) | ALDH1A1SMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL8147658 | 0.95 | PDCD1 (0.37) | PDCD1CD274ALDH1A1HTTHPGD | |
| SCHEMBL8149445 | 0.87 | TERT (0.36) | CD274SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL8149439 | 0.86 | CYP1A2 (0.38) | PDCD1CD274ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8365424 | 0.85 | — | — | |
| SCHEMBL8910714 | 0.84 | ALDH1A1 (0.34) | ALDH1A1HTTHPGDSMN1; SMN2KMT2A | |
| SCHEMBL8146941 | 0.84 | GRIN1 (0.39) | HPGDSMN1; SMN2POLBKDM4EBRD4 | |
| SCHEMBL8536552 | 0.82 | GAA (0.32) | ALDH1A1HTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL8516897 | 0.79 | KDM4E (0.33) | ALDH1A1HPGDKDM4E | |
| SCHEMBL8142555 | 0.79 | NPC1 (0.40) | POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |