Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628811 | 0.92 | SIGMAR1 (0.48) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL29960417 | 0.82 | CYP2D6 (0.47) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL17609064 | 0.76 | CYP2D6 (0.56) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL14359323 | 0.75 | DOCK5 (0.57) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL13100265 | 0.74 | NR3C1 (0.50) | SIGMAR1CYP2D6CYP3A4TSHRMEN1 | |
| Hydrochloric Acid SCHEMBL5422229 | 0.74 | DOCK5 (0.56) | SIGMAR1CYP2D6CYP3A4TSHRMEN1 | |
| SCHEMBL2915989 | 0.73 | CYP2D6 (0.59) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL3274284 | 0.71 | CYP2D6 (0.50) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL13090069 | 0.71 | NR3C1 (0.52) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL2344239 | 0.71 | SIGMAR1 (0.56) | SIGMAR1CYP2D6CYP3A4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287356-B1 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5132316-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| US-4971975-A | TREATMENT OF DEMENTIA; AZABICYCLOOCTANE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1990-11-20 | — | — | US | disclosed |
| EP-0287356-A2 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1988-10-19 | — | — | EP | disclosed |