Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3267961 | 0.86 | CYP2D6 (0.49) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 | |
| SCHEMBL3269979 | 0.84 | CYP2D6 (0.47) | CYP2D6CYP3A4TSHRRIPK1CYP1A2 | |
| SCHEMBL14359323 | 0.78 | DOCK5 (0.57) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL5422229 | 0.77 | DOCK5 (0.56) | CYP2D6CYP3A4TSHRSIGMAR1DRD2 | |
| SCHEMBL17611730 | 0.74 | CYP2D6 (0.47) | CYP2D6CYP3A4TSHRRIPK1CYP1A2 | |
| SCHEMBL3273039 | 0.74 | CYP2D6 (0.46) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 | |
| SCHEMBL3268276 | 0.74 | LTA4H (0.54) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 | |
| SCHEMBL23289929 | 0.73 | HDAC1 (0.64) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 | |
| SCHEMBL19693299 | 0.73 | CYP2D6 (0.54) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 | |
| SCHEMBL13100265 | 0.72 | NR3C1 (0.50) | CYP2D6CYP3A4TSHRCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071773-B2 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | NOVARTISAG (CH) | 2011-12-06 | — | — | US | disclosed |
| EP-1885724-B1 | HETEROCYCLIC SPIRO-COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2010-06-23 | — | — | EP | disclosed |
| US-20090111840-A1 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111840-A1 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | REN, NR3C2, CYP21A2 | CYP2D6 131/4885CYP3A4 147/4885TSHR 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.