Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046236 | 0.80 | ALDH1A1 (0.44) | MEN1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL2173608 | 0.70 | — | — | |
| SCHEMBL3838512 | 0.66 | NOS1 (0.46) | ALDH1A1MAPTSMN1; SMN2NOS1USP2 | |
| SCHEMBL12314726 | 0.64 | MYC (0.57) | NOS1USP2CYP1A2HRH2HRH1 | |
| SCHEMBL1607000 | 0.64 | MYC (0.48) | NPC1ALDH1A1MAPTRAB9APOLB | |
| SCHEMBL962001 | 0.64 | NOS1 (0.45) | MEN1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL925981 | 0.63 | MAPT (0.60) | MEN1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL4135470 | 0.63 | HSD17B10 (0.40) | NPC1MAPTRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1888770 | 0.62 | CDK4 (0.52) | MEN1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL7835676 | 0.62 | TGFBR1 (0.57) | MEN1NPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412404-B1 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-01-31 | — | — | EP | disclosed |
| CN-1027370-C | Process for preparing thiazole derivatives | FUJISAWA FARMACEUTICAL CO LTD (JP) | 1995-01-11 | — | — | CN | disclosed |
| US-5369107-A | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5256675-A | Antirheumatic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| CN-1049337-A | Thiazole derivative prepares their method, and the medicinal compositions that contains them | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-02-20 | — | — | CN | disclosed |
| EP-0412404-A2 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |