Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 15/20 | 0.39 |
| ▸ | LOX | P28300 | 3/20 | 0.39 |
| ▸ | LOXL3 | P58215 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048249 | 0.83 | NOS1 (0.46) | MYCWDR5DDAH1NOS1 | |
| Thiazolsulfone SCHEMBL152559 | 0.73 | ADORA3 (1.00) | ADORA3SLC6A3LOXL2LOXKCNH2 | |
| SCHEMBL1062382 | 0.73 | ADORA3 (0.75) | ADORA3SLC6A3LOXL2LOXLOXL3 | |
| SCHEMBL9048270 | 0.71 | ADORA3 (0.62) | ADORA3SLC6A3LOXL2LOXKCNH2 | |
| SCHEMBL5875692 | 0.70 | ADORA3 (0.76) | ADORA3SLC6A3LOXL2LOXKCNH2 | |
| SCHEMBL9426795 | 0.69 | PTGIR (0.42) | SLC6A3LOXMYCWDR5 | |
| SCHEMBL15587224 | 0.69 | MYC (0.47) | LOXL2LOXL3MYCWDR5NOS1 | |
| SCHEMBL5171580 | 0.69 | CYP3A4 (0.48) | ADORA3SLC6A3MYCWDR5NOS1 | |
| SCHEMBL9048451 | 0.67 | MYC (0.42) | MYCWDR5NOS1 | |
| SCHEMBL1062638 | 0.67 | ADORA3 (0.69) | ADORA3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412404-B1 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5369107-A | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5256675-A | Antirheumatic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| EP-0412404-A2 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |