SCHEMBL9050378

SCHEMBL9050378

N#Cc1ccc(C#Cc2ccc(Br)cc2F)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.49
HAO1 Q9UJM8 3/20 0.43
MAOB P27338 3/20 0.42
MAOA P21397 2/20 0.42
CYP11B1 P15538 2/20 0.39
CYP11B2 P19099 2/20 0.39
TRPV4 Q9HBA0 1/20 0.38
FFAR1 O14842 2/20 0.36
FFAR4 Q5NUL3 2/20 0.36
KIF11 P52732 1/20 0.36
GRM5 P41594 1/20 0.35
IDO1 P14902 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8645459 0.88 ACACB (0.45) ACACBHAO1MAOBMAOACYP11B1
SCHEMBL27214759 0.83 ACACB (0.46) ACACBCYP11B1CYP11B2TRPV4FFAR1
SCHEMBL22109247 0.83 ACACB (0.49) ACACBFFAR1FFAR4GRM5
SCHEMBL5139851 0.82 FFAR1 (0.51) ACACBHAO1FFAR1FFAR4GRM5
SCHEMBL17672970 0.79 CA12 (0.50) HAO1CYP11B1CYP11B2TRPV4FFAR1
SCHEMBL56634 0.79 TRPV4 (0.57) MAOBMAOACYP11B1CYP11B2TRPV4
SCHEMBL8979196 0.78 ALDH1A1 (0.53) HAO1CYP11B1CYP11B2TRPV4FFAR1
SCHEMBL8978989 0.78 ALDH1A1 (0.53) HAO1CYP11B1CYP11B2TRPV4FFAR1
SCHEMBL8621608 0.77 MAOB (0.64) MAOBMAOAIDO1
SCHEMBL8978813 0.76 ACACB (0.56) ACACBFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8012599-A None JP disclosed
JP-H0812599-A PRODUCTION OF TOLAN COMPOUND SUMITOMO CHEM CO LTD 1996-01-16 JP disclosed