SCHEMBL9052002

SCHEMBL9052002

O=C(/C=C/C(=O)On1cnc2c1CCC(C(=O)c1csc3ccccc13)C2)On1cnc2c1CCC(C(=O)c1csc3ccccc13)C2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
HTT P42858 3/20 0.35
HPGD P15428 2/20 0.35
LMNA P02545 1/20 0.35
HSD17B10 Q99714 4/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
C5AR1 P21730 3/20 0.34
ALOX15 P16050 1/20 0.34
P2RX7 Q99572 1/20 0.34
HTR3A P46098 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
HDAC6 Q9UBN7 2/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9052108 0.81 HTR3A (0.46) ALDH1A1SMN1; SMN2HTTLMNACYP2D6
SCHEMBL9048666 0.80 ADRA2A (0.55) ALDH1A1SMN1; SMN2CYP1A2CYP2D6CYP2C9
SCHEMBL9052277 0.80 ADRA2A (0.55) ALDH1A1SMN1; SMN2CYP1A2CYP2D6CYP2C9
SCHEMBL9048682 0.78 NPSR1 (0.40) ALDH1A1SMN1; SMN2LMNAHTR3AADRA2A
SCHEMBL9051976 0.77 NPSR1 (0.40) ALDH1A1SMN1; SMN2LMNAHTR3AADRA2A
SCHEMBL9050459 0.76 RAB9A (0.39) ALDH1A1SMN1; SMN2HTTLMNAHSD17B10
SCHEMBL9051282 0.76 CNR2 (0.48) ALDH1A1SMN1; SMN2HTR3AADRA2AADRA2B
SCHEMBL9051421 0.76 CNR1 (0.49) SMN1; SMN2LMNATP53CNR2MAPT
SCHEMBL3178647 0.72 HTR3A (0.51) ALDH1A1SMN1; SMN2HTTHPGDLMNA
SCHEMBL9051218 0.71 TSHR (0.51) ALDH1A1HTTHPGDLMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0381422-B1 Tetrahydrobenzimidazole derivatives YAMANOUCHI PHARMA CO LTD (JP) 1996-10-23 EP disclosed
US-5496942-A 5-HT3-RECEPTOR ANTAGONISTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1996-03-05 US disclosed
US-5344927-A 5-HT3 antagonist YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1994-09-06 US disclosed
EP-0381422-A1 Tetrahydrobenzimidazole derivatives YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1990-08-08 EP disclosed