Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318136 | 0.94 | CHRM2 (0.44) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL9049463 | 0.93 | CHRM2 (0.47) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL9048446 | 0.89 | CHRM2 (0.42) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| SCHEMBL9050441 | 0.87 | CHRM2 (0.50) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| SCHEMBL9052128 | 0.82 | CHRM2 (0.45) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL8791271 | 0.81 | CHRM2 (0.39) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| SCHEMBL28436716 | 0.81 | HSD11B1 (0.40) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL9523436 | 0.75 | CHRM2 (0.51) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL8790010 | 0.74 | CHRM2 (0.41) | CHRM1CHRM2CHRM4CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL6627162 | 0.74 | CHRM2 (0.50) | CHRM1CHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287356-B1 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5132316-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| US-4971975-A | TREATMENT OF DEMENTIA; AZABICYCLOOCTANE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1990-11-20 | — | — | US | disclosed |
| EP-0287356-A2 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1988-10-19 | — | — | EP | disclosed |