Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8791271 | 0.94 | CHRM2 (0.39) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL9052128 | 0.92 | CHRM2 (0.45) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL9050441 | 0.89 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL9048446 | 0.87 | CHRM2 (0.42) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| Oxalic Acid SCHEMBL9049463 | 0.84 | CHRM2 (0.47) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL3318136 | 0.79 | CHRM2 (0.44) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL8523645 | 0.77 | CHRM2 (0.38) | CHRM2CHRM4CHRM1CHRM3USP2 | |
| Oxalic Acid SCHEMBL9051874 | 0.74 | CHRM1 (0.41) | CHRM2CHRM4CHRM1CHRM3NPSR1 | |
| SCHEMBL8790867 | 0.74 | CHRM2 (0.35) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL28436716 | 0.74 | HSD11B1 (0.40) | CHRM2CHRM4CHRM1CHRM3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413545-B1 | Azabicyclic compounds | BEECHAM GROUP PLC (GB) | 1997-05-14 | — | — | EP | claimed |
| US-5157160-A | Treatment of diseases of the nervous system | BEECHAM GROUP P.L.C. (GB) | 1992-10-20 | — | — | US | claimed |
| EP-0413545-A2 | Azabicyclic compounds | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | claimed |
| EP-0413545-B1 | Azabicyclic compounds | BEECHAM GROUP PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| US-5157160-A | Treatment of diseases of the nervous system | BEECHAM GROUP P.L.C. (GB) | 1992-10-20 | — | — | US | disclosed |
| US-5043343-A | Certain 5-substituted-1-aza-bicyclo[3.3.3]heptanes and their pharmaceutical compositions and methods | BEECHAM GROUP P.L.C. (GB) | 1991-08-27 | — | — | US | disclosed |
| EP-0413545-A2 | Azabicyclic compounds | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | disclosed |