Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029312 | 0.86 | FTO (0.47) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL15778575 | 0.86 | FTO (0.47) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL4885766 | 0.86 | FTO (0.47) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL11310755 | 0.84 | FTO (0.52) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL7646663 | 0.84 | FTO (0.52) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL183875 | 0.84 | FTO (0.52) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL1978381 | 0.84 | FTO (0.52) | FTOHPGDMAPTMEN1CYP2C19 | |
| 1,3-Propanediol SCHEMBL28547758 | 0.84 | FTO (0.46) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL9428188 | 0.81 | FTO (0.56) | FTOHPGDMAPTMEN1CYP2C19 | |
| SCHEMBL5149281 | 0.80 | FTO (0.55) | FTOHPGDMAPTMEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160280747-A1 | ANTICALINS | PIERIS AG (DE) | 2016-09-29 | — | — | US | disclosed |
| US-20140080177-A1 | ANTICALINS | PIERIS AG (DE) | 2014-03-20 | — | — | US | disclosed |
| US-8536307-B2 | Anticalins | PIERIS AG (DE) | 2013-09-17 | — | — | US | disclosed |
| US-20120244596-A1 | ANTICALINS | PIERIS AG | 2012-09-27 | — | — | US | disclosed |
| US-8158753-B2 | Anticalins | PIERIS AG (DE) | 2012-04-17 | — | — | US | disclosed |
| EP-1270725-B1 | Anticalines | PIERIS AG (DE) | 2011-01-19 | — | — | EP | disclosed |
| US-20100285564-A1 | Anticalins | PIERIS AG | 2010-11-11 | — | — | US | disclosed |
| US-7723476-B2 | Anticalins | PIERIS AG (DE) | 2010-05-25 | — | — | US | disclosed |
| US-7250297-B1 | Anticalins | PIERIS AG (DE) | 2007-07-31 | — | — | US | disclosed |
| US-20060058510-A1 | Lipocalins having a cylindrical beta-pleated sheet of eight beta -strands connected pair-wise by four peptide loops to define a bindingpocket; sequences of bilin-binding protein of Pieris brassicae; genetic engineering; mutants; small chemical, peptide epitopes with determinable affinity >105 M-1 | SKERRA, ARNE (DE) | 2006-03-16 | — | — | US | disclosed |
| EP-1270725-A1 | Anticalines | Pieris ProteoLab AG (DE) | 2003-01-02 | — | — | EP | disclosed |
| EP-1017814-B1 | ANTICALINS | PIERIS PROTEOLAB AG (DE) | 2002-10-16 | — | — | EP | disclosed |
| EP-1017814-A1 | ANTICALINS | Skerra, Arne (DE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999016873-A1 | ANTICALINS | SKERRA ARNE (DE) | 1999-04-08 | — | — | WO | disclosed |